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# Tafenoquine MOA - Free radical mediated killing of hypnozooites Indication - Single dose radical cure of P. vivax malaria # Tenapanor MOA -NHE-3 inhibitor Indication - IBS with constipation # Tolvaptan MOA -Vasopressin V2 receptor antagonist Indication - To slow kidney function decline in adult polycystic kidney disease
Good evening doctors,We are very happy about your responses for KONCPT APP so far.A kind request to spare a few minutes and fill in this form for further betterment of the APP and the future PG aspirants.To fill the form, click the link below https://forms.gle/Jht3Lf8RVC1Y...
JVP has three upward deflections and 2 downward deflections Upward deflections : a,c and v wave Downward deflections: x and y a wave - Due to atrial contraction c wave – Due to bulging of tricuspid valves v wave – Due to systolic filling of the atrium x descent – Due to atrial relaxation y descent – Due to early ventricular filling Prominent a wave is seen in Pulmonary hypertension, tricuspid regurgitation Absent a wave is seen in atrial fibrillation Absent x descent seen in atrial fibrillation and tricuspid regurgitation Prominent v wave is seen in right ventricular failure and tricuspid regurgitation Rapid y descent is seen in tricuspid regurgitation and right ventricular failure Slow y descent is seen in tricuspid stenosis
STRUCTURES PASSING THROUGH DIFFERENT OPENING IN DIAPHRAGM: Remember the pneumonic (Voice Of America -8,10,12) Voice (Venacaval opening) – T8 Inferior vena cava Right phrenic nerve Of (Esophageal opening) – T10 Esophagus Esophageal branch of left gastric artery Anterior and posterior vagal trunks Tributaries of left gastric vein America (Aortic opening) – T12 Abdominal aorta Thoracic duct Azygous vein Behind the medial arcuate ligament: Sympathetic trunk and least splanchnic nerve Behind the lateral arcuate ligament: Subcostal nerve and vessels
