ANSWER FOR YESTERDAY'S CONCEPTUAL QUESTION
Published on April 18, 2020, 10:43 p.m.

Ans: d. Anti mitochondrial antibody

  • The given history is that of a middle aged female with pruritis, elevated bilirubin levels, increased levels of serum alkaline phosphatase and gamma glutamyl transferase.
  • Serum alkaline phosphatase and gamma glutamyl transferase are markers of cholestasis.
  • The given biopsy shows florid duct lesions with portal based granulomatous inflammation.
  • The histopathology of colonic biopsy is normal.
  • The given condition is autoimmune condition – Primary biliary cirrhosis
  • 90%  of the patient with this condition shows Antimitochondrial body.
  • Few patients can show the presence of ANA and ANCA
  • Primary biliary cirrhosis can be associated with Sjogren’s syndrome, scleroderma or thyroid disease.
  • Antigliadin, anti endomysial and anti tissue transglutaminase  antibodies can be seen in Celiac disease
  • Anti Saccharomyces cerevisiae antibody is present in patients with ulcerative colitis